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KMID : 1161420190220060551
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Journal of Medicinal Food
2019 Volume.22 No. 6 p.551 ~ p.559
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Effects of an Oil-Free Hydroethanolic Pumpkin Seed Extract on Symptom Frequency and Severity in Men with Benign Prostatic Hyperplasia: A Pilot Study in Humans
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Leibbrand Martin
Siefer Simone
Schon Christiane
Perrinjaquet-Moccetti Tania
Kompek Albert
Csernich Anca
Bucar Franz
Kreuter Matthias Heinrich
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Abstract
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Majority of men are affected by symptomatic benign prostatic hyperplasia (BPH) from a certain age. Botanical extracts are frequently used in the early management of the symptoms. In a single-arm, mono-center pilot study, the effects of a proprietary oil-free hydroethanolic pumpkin seed extract on the symptoms of BPH were investigated. A total of 60 men (62.3 years [95% confidence interval (CI): 60.3?64.3 years]) with a total International Prostate Symptom Score (IPSS) of 14.8 (95% CI: 13.5?16.1) participated between January 2017 and October 2017 in the study by ingesting the oil-free hydroethanolic pumpkin seed extract once daily before going to bed during 3 months. Change in IPSS within treatment period was assessed. Frequency of nocturia was recorded by bladder diary, and postvoid residual urine volume was determined through ultrasound. Between baseline and after 12 weeks of supplementation, a significant symptom reduction of an average 30.1% (95% CI: 23.1?37.1) was seen for the total IPSS. Symptom alleviation had a high impact on quality of life (P?
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KEYWORD
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benign prostatic hyperplasia, Cucurbita pepo L., International Prostate Symptom Score, lower urinary tract symptoms, nocturia, pumpkin seeds
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